Methods to improve drug delivery efficiency through blood-brain barrier disruption (BBBD) based on microbubbles and focused ultrasound (FUS) are continuously being studied.However, most studies are being conducted in preclinical trial environments using small animals.The use of the human skull shows differences between the clinical and preclinical
Within the last decade, archaeogenetic analysis has revolutionized archaeological research and enabled novel insights into mobility, relatedness and health of past Tripod societies.Now, it is possible to develop these results further and integrate archaeogenetic insights into biological relatedness with radiocarbon dates as means of chronologically
In recent years, tremendous progress has been made in understanding the roles of extracellular vesicles (EVs) in cancer.Thanks to advancements in molecular biology, it has been found that the fraction of EVs called exosomes or small EVs (sEVs) modulates the sensitivity of cancer cells to chemotherapeutic agents by delivering molecularly active non-
Recreational activities, free and organised play are necessary in the life of a child.The final aim of 203 this paper is to analyse the needs for and benefits of recreational activities for refugee and internally displaced children and youngsters living in refugee or IDP camps, as well as the efforts made by the international community encouraging